Medical Marijuana and Amyloidosis

amyloidosis and medical marijuana Okay, how often have you seen Amyloidosis on the list of conditions suitable for medical marijuana treatment and wondered what on earth it is? You are probably not alone; I’ll let you into a secret: I’m a health professional and I didn’t have a clue and had to look it up! So, in brief:

Amyloids are body-proteins that have folded in on themselves, making them insoluble. The fact that they don’t dissolve can lead to a build up of deposits in various organs, such as the heart, the kidneys, and the nerves. This accumulation interferes with the functioning of the organ. I imagine it as being a bit like a build up of calcium deposits in a kettle. A build up of amyloids is known as amyloidosis. With me so far? Good, because now it gets a little more complex: there are more than 20 proteins that may form amyloids, meaning that amyloidosis is not one disease but a whole collection.

Types of Amyloidosis

There are three main types of amyloidosis:

  • Primary amyloidosis
  • Secondary amyloidosis
  • Hereditary amyloidosis

Primary Amyloidosis

The most common form of this very rare disease is primary amyloidosis, a disorder of blood plasma affecting the bone marrow; you may also see this disease referred to as:

  • Light chain amyloidosis
  • AL amyloidosis

The build-up of the amyloid protein primarily affects the heart, kidneys, lungs, skin, tongue, nerves, and intestines. It may also occur in association with multiple myeloma.

Secondary Amyloidosis

Secondary amyloidosis, also referred to as AA, occurs as a result of a pre-existing inflammatory condition or chronic infection – the most common pre-disposing disease is rheumatoid arthritis. Symptoms of AA may include protein in the urine, oedema, and extreme fatigue. Treatment will depend on the underlying disease, which must be brought under control if the amyloidosis is to be addressed.

Because the amyloid fibrils in AA Amyloidosis are deposited mainly in the liver, spleen and kidneys, the most common presentation is kidney failure. Complications in the digestive tract are frequent and present as chronic diarrhoea with bleeding, abdominal pain and poor absorption of nutrients.

Hereditary Amyloidosis

Hereditary amyloidoses are rare, at less than 1 per 100,000 of the population. Treatments for these variants of amyloidosis are not advanced but, fortunately, the hereditary variants of the disease are slow progressing and mostly limited to the kidney.

Signs and Symptoms of Amyloidosis

The signs and symptoms of amyloidosis depend on the location and size of the amyloid deposits and any organ or tissue may be affected; the signs and symptoms can also be vague and difficult to pinpoint. They include the following:

  • Irregular heart beat and heart disease: over one-third of amyloidosis patients have a heart condition
  • Stroke
  • Kidney disorders, including kidney failure
  • Gastrointestinal (GI) disorders; these include: perforation of the gut, bleeding, delayed movement of matter through the GI tract, blockage of the GI tract
  • Enlarged liver
  • Poor spleen function
  • Poor function of the adrenal glands and other hormone producing glands
  • Skin conditions, including color changes, pinprick bleeding into the skin around the eyes (shows as tiny red/purple spots), easy bruising
  • Enlarged tongue, sometimes with swelling under the jaw, difficulty breathing
  • Lung problems
  • Swelling of the shoulder joints (may look like shoulder pads under the skin)

Traditional Drug Treatments for Amyloidosis

  • A combination of Prednisilone (a corticosteroid) and Alkeran (used in some forms of cancer)
  • Diuretics to relieve fluid retention and so ease oedema
  • Anti-arrhythmics to control heart rhythm
  • Metoclopramide to help fight nausea

Medical Marijuana and Amyloidosis

Perhaps you haven’t noticed, but the conditions that are helped by medical marijuana tend to exhibit one or more of the following characteristics:

  • Inflammation
  • Nausea
  • Dysfunctional immune system
  • Traditional drug therapy causes difficult side effects, for instance, nausea

It has been known for a very long time that cannabis has anti-inflammatory properties and we now understand that it is the CBD content of the plant that imparts these characteristics. Plants high in CBD have been shown to be capable of reducing pain, inflammation, stomach cramps and nausea. And, as an added benefit, these high CBD strains of cannabis also reduce anxiety.

You may find the following medical marijuana strains helpful for symptom control in Amyloidosis:

  • Digestive Disorders: Blueberry, Blackberry, Black Domina
  • Nausea, Pain, and Diarrhoea: Blueberry
  • Chronic pain: Blueberry
  • Nausea and Pain: Afghanica
  • Pain and Nausea: AK-47
  • Nausea, joint pain, and arthritis: Aurora B
  • Nausea: Cali-O
  • Nausea: Cinderella 99
  • Oedema, epilepsy, fibromyalgia, and radiculopathy: NYC Sour Diesel
  • Nausea, depression: Kali Mist
  • Nausea: Nausea
  • Nausea: skunk # 1

The best way of ensuring you get exactly the right strain for your condition is, of course, to grow your own marijuana

Tags: ,

Comments

  1. Pingback: Medical Marijuana Benefits, Helps These Conditions

Leave a comment

captcha

Popular Forum Threads

  • How to get a medical marijuana card

    Just trying to spread the word about a sweet site that is showing people how to get a medical marijuana card in california and 13 other states.

    Read more >
  • Growing marijuana for medical marijuana patient

    I have a friend who is eligible for Medical Marijuana. He knows someone who wants to grow Marijuana and distribute it to him and other patients, I guess they are called "caregivers?" For the record they have gone to a clas to learn how to do this process. I have several questions that I need answered before Saturday.

    Read more >
  • Obtaining pot from another state

    If you live in a state (fla) that doesn't support medical weed, and if you have a card from another state, is it possible to obtain the cannabis from a state that does cater to us? Mail , ups, fed ex ?

    Read more >
  • Vaporizer Corner - Get Started

    I love my vapes. I have many, and have tried most. Each has a learning curve to it, especially the portable ones. You have to take a day to learn each.. and most new Vaporists think that they are not that crazy about their choice on the first couple of tries.

    Read more >
  • The Herbal Review

    I just got my VaporBlunt 2.0 and might have found my new love. I'm going to use it a bit more over the weekend, and hopefully make a full video review next week; after I get a better understanding/feel for the vape.

    Read more >
  • Vaporizers

    What are the types of Vaporizers available in the market?

    Read more >